Gene

LYNX1

Species
Homo sapiens
Symbol
LYNX1
Name
Ly6/neurotoxin 1
Synonyms
  • endogenous prototoxin LYNX1
  • Ly-6 neurotoxin-like protein 1
Biotype
protein coding gene
Automated Description
Enables acetylcholine receptor binding activity and acetylcholine receptor regulator activity. Involved in regulation of neurotransmitter receptor activity. Predicted to be located in membrane. Predicted to be active in plasma membrane.
RGD Description
This gene encodes a GPI-anchored, cell membrane bound member of the Ly6/uPAR (LU) superfamily of proteins containing the unique three-finger LU domain. This protein interacts with nicotinic acetylcholine receptors (nAChRs), and is thought to function as a modulator of nAChR activity to prevent excessive excitation. Alternatively spliced transcript variants have been found for this gene. Read-through transcription between this gene and the neighboring downstream gene (SLURP2) generates naturally-occurring transcripts (LYNX1-SLURP2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Sep 2017]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR16983
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
142.772M142.773M142.774M142.775M142.776M142.777M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions