Gene

DOC2A

Species
Homo sapiens
Symbol
DOC2A
Name
double C2 domain alpha
Synonyms
  • Doc2
  • doc2-alpha
Biotype
protein coding gene
Automated Description
Predicted to enable calcium-dependent phospholipid binding activity and metal ion binding activity. Involved in regulation of calcium ion-dependent exocytosis. Located in cell junction; nucleolus; and nucleoplasm.
RGD Description
There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2A is mainly expressed in brain and is suggested to be involved in Ca(2+)-dependent neurotransmitter release. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45729
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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      Alleles and Variants

      Allele/Variant Symbol
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      Variant
      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
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        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCh38
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            30.006M30.008M30.010M30.012M30.014M30.016M30.018M30.020M30.022M

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            DOC2A molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
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              Genetic Interactions

              DOC2A role
              DOC2A genetic perturbation
              Interactor gene
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