Enables deubiquitinase activator activity; double-stranded DNA binding activity; and single-stranded DNA binding activity. Involved in DNA damage response; positive regulation of double-strand break repair via homologous recombination; and positive regulation of receptor signaling pathway via JAK-STAT. Located in nucleus. Is active in cytoplasm.
RGD Description
The protein encoded by this gene has been shown to interact with ubiquitin specific peptidase 1 (USP1), activating the deubiquitinating activity of USP1 and allowing it to remove the ubiquitin moiety from monoubiquitinated FANCD2. FANCD2 is ubiquitinated in response to DNA damage. [provided by RefSeq, Sep 2016]