Gene

WDR48

Species
Homo sapiens
Symbol
WDR48
Name
WD repeat domain 48
Synonyms
  • Bun62
  • DKFZp686G1794
Biotype
protein coding gene
Automated Description
Enables deubiquitinase activator activity; double-stranded DNA binding activity; and single-stranded DNA binding activity. Involved in DNA damage response; positive regulation of double-strand break repair via homologous recombination; and positive regulation of receptor signaling pathway via JAK-STAT. Located in nucleus. Is active in cytoplasm.
RGD Description
The protein encoded by this gene has been shown to interact with ubiquitin specific peptidase 1 (USP1), activating the deubiquitinating activity of USP1 and allowing it to remove the ubiquitin moiety from monoubiquitinated FANCD2. FANCD2 is ubiquitinated in response to DNA damage. [provided by RefSeq, Sep 2016]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR19862
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
39.055M39.060M39.065M39.070M39.075M39.080M39.085M39.090M39.095M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions