Enables lysophosphatidic acid binding activity and lysophosphatidic acid receptor activity. Involved in several processes, including negative regulation of cilium assembly; phospholipase C-activating G protein-coupled receptor signaling pathway; and positive regulation of canonical NF-kappaB signal transduction. Located in cell surface; cytoplasmic vesicle; and plasma membrane.
RGD Description
The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Many transcript variants encoding a few different isoforms have been identified for this gene. [provided by RefSeq, Oct 2020]