Gene

LPAR1

Species
Homo sapiens
Symbol
LPAR1
Name
lysophosphatidic acid receptor 1
Synonyms
  • edg-2
  • EDG2
Biotype
protein coding gene
Automated Description
Enables lysophosphatidic acid binding activity and lysophosphatidic acid receptor activity. Involved in several processes, including negative regulation of cilium assembly; phospholipase C-activating G protein-coupled receptor signaling pathway; and positive regulation of canonical NF-kappaB signal transduction. Located in cell surface; cytoplasmic vesicle; and plasma membrane.
RGD Description
The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Many transcript variants encoding a few different isoforms have been identified for this gene. [provided by RefSeq, Oct 2020]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR22750
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
110.88M110.90M110.92M110.94M110.96M110.98M111.00M111.02M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions