Gene

S1PR2

Species
Homo sapiens
Symbol
S1PR2
Name
sphingosine-1-phosphate receptor 2
Synonyms
  • AGR16
  • CTD-2369P2.2
Biotype
protein coding gene
Automated Description
Enables G protein-coupled receptor activity and signaling receptor binding activity. Involved in several processes, including positive regulation of establishment of endothelial barrier; positive regulation of peptidyl-threonine phosphorylation; and sphingosine-1-phosphate receptor signaling pathway. Acts upstream of or within G protein-coupled receptor signaling pathway. Located in plasma membrane. Implicated in autosomal recessive nonsyndromic deafness 68.
RGD Description
This gene encodes a member of the G protein-coupled receptors, as well as the EDG family of proteins. The encoded protein is a receptor for sphingosine 1-phosphate, which participates in cell proliferation, survival, and transcriptional activation. Defects in this gene have been associated with congenital profound deafness. [provided by RefSeq, Mar 2016]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR22750
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCh38
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          S1PR2 molecule type
          Interactor gene
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          Interactor molecule type
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            Genetic Interactions

            S1PR2 role
            S1PR2 genetic perturbation
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            Interactor genetic perturbation
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