Gene

EDNRA

Species
Homo sapiens
Symbol
EDNRA
Name
endothelin receptor type A
Synonyms
  • endothelin A receptor
  • endothelin ET-A receptor
Biotype
protein coding gene
Automated Description
Predicted to enable endothelin receptor activity. Involved in several processes, including artery smooth muscle contraction; cAMP/PKA signal transduction; and positive regulation of cation channel activity. Predicted to be located in membrane. Predicted to be active in plasma membrane. Implicated in hypertension (multiple); lung disease; mandibulofacial dysostosis with alopecia; migraine; and obstructive sleep apnea. Biomarker of pulmonary hypertension.
RGD Description
This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR46099
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
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147.49M147.50M147.51M147.52M147.53M147.54M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions