Gene

INS-IGF2

Species
Homo sapiens
Symbol
INS-IGF2
Name
INS-IGF2 readthrough
Synonyms
  • INS-IGF2 readthrough transcript protein
  • INSIGF
Biotype
protein coding gene
Automated Description
Predicted to enable hormone activity. Predicted to be involved in insulin receptor signaling pathway. Predicted to act upstream of with a positive effect on receptor internalization. Predicted to be located in cytosol. Predicted to be active in extracellular space.
RGD Description
This locus includes two alternatively spliced read-through transcript variants which align to the INS gene in the 5' region and to the IGF2 gene in the 3' region. One transcript is predicted to encode a protein which shares the N-terminus with the INS protein but has a distinct and longer C-terminus, whereas the other transcript is a candidate for nonsense-mediated decay (NMD). The transcripts are imprinted and are paternally expressed in the limb and eye. [provided by RefSeq, Jul 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11454
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
2.130M2.135M2.140M2.145M2.150M2.155M2.160M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions