Predicted to enable hormone activity. Predicted to be involved in insulin receptor signaling pathway. Predicted to act upstream of with a positive effect on receptor internalization. Predicted to be located in cytosol. Predicted to be active in extracellular space.
RGD Description
This locus includes two alternatively spliced read-through transcript variants which align to the INS gene in the 5' region and to the IGF2 gene in the 3' region. One transcript is predicted to encode a protein which shares the N-terminus with the INS protein but has a distinct and longer C-terminus, whereas the other transcript is a candidate for nonsense-mediated decay (NMD). The transcripts are imprinted and are paternally expressed in the limb and eye. [provided by RefSeq, Jul 2008]