Gene

EP300

Species
Homo sapiens
Symbol
EP300
Name
E1A binding protein p300
Synonyms
  • E1A-associated protein p300
  • E1A-binding protein, 300kD
Biotype
protein coding gene
Automated Description
Enables several functions, including N-acyltransferase activity; RNA polymerase II-specific DNA-binding transcription factor binding activity; and beta-catenin binding activity. Involved in several processes, including protein acylation; regulation of primary metabolic process; and regulation of signal transduction. Located in nucleoplasm. Is active in chromatin and cytosol. Implicated in Rubinstein-Taybi syndrome; colorectal cancer; and congestive heart failure. Biomarker of several diseases, including Alzheimer's disease; cardiac arrest; clear cell renal cell carcinoma; idiopathic pulmonary fibrosis; and prostate cancer.
RGD Description
This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13808
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
41.10M41.11M41.12M41.13M41.14M41.15M41.16M41.17M41.18M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions