Enables several functions, including N-acyltransferase activity; RNA polymerase II-specific DNA-binding transcription factor binding activity; and beta-catenin binding activity. Involved in several processes, including protein acylation; regulation of primary metabolic process; and regulation of signal transduction. Located in nucleoplasm. Is active in chromatin and cytosol. Implicated in Rubinstein-Taybi syndrome; colorectal cancer; and congestive heart failure. Biomarker of several diseases, including Alzheimer's disease; cardiac arrest; clear cell renal cell carcinoma; idiopathic pulmonary fibrosis; and prostate cancer.
RGD Description
This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008]