Gene

TMED7-TICAM2

Species
Homo sapiens
Symbol
TMED7-TICAM2
Name
TMED7-TICAM2 readthrough
Synonyms
  • FLJ90737
  • MyD88-4
Biotype
protein coding gene
Automated Description
Enables molecular adaptor activity. Involved in several processes, including positive regulation of interleukin-18-mediated signaling pathway; regulation of cytokine production; and regulation of innate immune response. Located in several cellular components, including endoplasmic reticulum-Golgi intermediate compartment; endosome; and phagocytic cup. Is active in endosome membrane.
RGD Description
This locus represents naturally occurring read-through transcription between the neighboring transmembrane emp24 protein transport domain containing 7 (TMED7) and toll-like receptor adaptor molecule 2 (TICAM2) genes. Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity with the products of each individual gene. This fusion product functions to negatively regulate the adaptor MyD88-independent toll-like receptor 4 pathway. [provided by RefSeq, Nov 2010]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR22811
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
115.580M115.585M115.590M115.595M115.600M115.605M115.610M115.615M115.620M115.625M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions