Predicted to enable peroxidase activity. Predicted to be involved in defense response to bacterium. Predicted to act upstream of or within defense response to nematode; eosinophil migration; and regulation of cytokine production. Located in extracellular exosome. Biomarker of allergic asthma and asthma.
RGD Description
This gene is a member of the peroxidase gene family and is expressed in eosinophils. The encoded preproprotein is proteolytically processed into covalently attached heavy and light chains to form the mature enzyme, which functions as an oxidant. The enzyme is released at sites of parasitic infection or allergen stimulation to mediate lysis of protozoa or parasitic worms. The gene is found in a gene cluster with other peroxidase genes on chromosome 17. Mutations in this gene result in eosinophil peroxidase deficiency. [provided by RefSeq, Feb 2016]