Version: 8.0.0
Date: Tue Jan 28 2025
FABP3
Homo sapiensHGNC:3557
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

FABP3

Species
Homo sapiens
Symbol
FABP3
Name
fatty acid binding protein 3
Synonyms
  • FABP11
  • fatty acid binding protein 11
Biotype
protein coding gene
Automated Description
Enables cytoskeletal protein binding activity and oleic acid binding activity. Predicted to be involved in several processes, including cholesterol homeostasis; phospholipid homeostasis; and positive regulation of long-chain fatty acid import into cell. Predicted to act upstream of or within brown fat cell differentiation and regulation of phosphatidylcholine biosynthetic process. Located in extracellular space. Implicated in hypertension and type 2 diabetes mellitus. Biomarker of Alzheimer's disease; Down syndrome; myocardial infarction; and obesity.
RGD Description
The intracellular fatty acid-binding proteins (FABPs) belongs to a multigene family. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Fatty acid-binding protein 3 gene contains four exons and its function is to arrest growth of mammary epithelial cells. This gene is a candidate tumor suppressor gene for human breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11955
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCh38
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          FABP3 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
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            Genetic Interactions

            FABP3 role
            FABP3 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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