Gene

AKAP10

Species
Homo sapiens
Symbol
AKAP10
Name
A-kinase anchoring protein 10
Synonyms
  • A kinase (PRKA) anchor protein 10
  • a kinase anchor protein 10
Biotype
protein coding gene
Automated Description
Enables protein kinase A binding activity. Predicted to be involved in protein localization. Located in cytosol and plasma membrane. Part of protein-containing complex.
RGD Description
This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins bind to the regulatory subunits of protein kinase A (PKA) and confine the holoenzyme to discrete locations within the cell. The encoded protein is localized to mitochondria and interacts with both the type I and type II regulatory subunits of PKA. Polymorphisms in this gene may be associated with increased risk of arrhythmias and sudden cardiac death. [provided by RefSeq, May 2012]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13155
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Mus musculusAkap109 of 10YesYes  
Rattus norvegicusAkap109 of 10YesYes  
Xenopus laevisakap10.L1 of 1YesYes           
Xenopus tropicalisakap105 of 9YesYes   
Danio rerioakap1010 of 10YesYes  
Drosophila melanogasterpkaap9 of 9YesYes   
Caenorhabditis elegansrgs-57 of 9YesYes   
Saccharomyces cerevisiaeRAX12 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

No paralogs for the gene.

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
19.91M19.92M19.93M19.94M19.95M19.96M19.97M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

35 interactor genes based on 40 annotations
AKAP10 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
ARFGEF1Homo sapiens
protein
  • affinity chromatography technology
PMID:35271311
protein
ARFGEF2Homo sapiens
protein
  • affinity chromatography technology
PMID:35271311
protein
ATG16L1Homo sapiens
protein
  • proximity labelling technology
PMID:37689310
protein
COG3Homo sapiens
protein
  • biochemical
PMID:22863883
protein
DCTN4Homo sapiens
protein
  • biochemical
PMID:22863883
protein
DISC1Homo sapiens
protein
  • two hybrid fragment pooling approach
PMID:31413325
protein
DUSP9Homo sapiens
protein
  • affinity chromatography technology
PMID:28675297
protein
EEF1AKMT3Homo sapiens
protein
  • affinity chromatography technology
PMID:33961781
protein
HAX1Homo sapiens
protein
  • affinity chromatography technology
PMID:20171186
protein
IKZF3Homo sapiens
protein
  • two hybrid
PMID:26871637
Showing 1 - 10 of 40 rows
per page

Genetic Interactions