Gene

FGG

Species
Homo sapiens
Symbol
FGG
Name
fibrinogen gamma chain
Synonyms
  • fibrinogen, gamma polypeptide
  • testicular tissue protein Li 70
Biotype
protein coding gene
Automated Description
Enables cell adhesion molecule binding activity; signaling receptor binding activity; and structural molecule activity. Involved in several processes, including blood coagulation; negative regulation of apoptotic process; and positive regulation of secretion by cell. Located in external side of plasma membrane; extracellular space; and platelet alpha granule. Part of fibrinogen complex. Implicated in brain small vessel disease; congenital afibrinogenemia; and multiple myeloma. Biomarker of type 2 diabetes mellitus.
RGD Description
The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR47221
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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None
Other Sources
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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    Alleles and Variants

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      Transgenic Alleles

      Species
      (carrying the transgene)
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCh38
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          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          FGG molecule type
          Interactor gene
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            Genetic Interactions

            FGG role
            FGG genetic perturbation
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