Gene

FKBP6

Species
Homo sapiens
Symbol
FKBP6
Name
FKBP prolyl isomerase family member 6 (inactive)
Synonyms
  • 36 kDa FK506-binding protein
  • 36 kDa FKBP
Biotype
protein coding gene
Automated Description
Enables identical protein binding activity. Involved in positive regulation of viral genome replication. Predicted to be located in cytosol and synaptonemal complex. Predicted to be active in cytoplasm. Implicated in Williams-Beuren syndrome and spermatogenic failure 77.
RGD Description
The protein encoded by this gene is a cis-trans peptidyl-prolyl isomerase that may function in immunoregulation and basic cellular processes involving protein folding and trafficking. This gene is located in a chromosomal region that is deleted in Williams-Beuren syndrome. Defects in this gene may cause male infertility. There are multiple pseudogenes for this gene located nearby on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR46674
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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      Alleles and Variants

      Allele/Variant Symbol
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      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCh38
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            73.330M73.335M73.340M73.345M73.350M73.355M

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            FKBP6 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
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              Genetic Interactions

              FKBP6 role
              FKBP6 genetic perturbation
              Interactor gene
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