Version: 8.0.0Date: Tue Jan 28 2025
Gene
FN1
- Species
- Homo sapiens
- Symbol
- FN1
- Name
- fibronectin 1
- Synonyms
- CIG
- cold-insoluble globulin
- Biotype
- protein coding gene
- Automated Description
- Enables several functions, including identical protein binding activity; integrin binding activity; and protease binding activity. Involved in several processes, including integrin activation; regulation of intracellular signal transduction; and regulation of macromolecule metabolic process. Located in collagen-containing extracellular matrix; endoplasmic reticulum-Golgi intermediate compartment; and extracellular exosome. Part of fibrinogen complex. Is active in extracellular matrix. Implicated in calcium oxalate nephrolithiasis; membranoproliferative glomerulonephritis; and spondylometaphyseal dysplasia corner fracture type. Biomarker of several diseases, including Sturge-Weber syndrome; end stage renal disease; glomerulonephritis (multiple); osteoarthritis; and urinary system cancer (multiple).
- RGD Description
- This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined. [provided by RefSeq, Jan 2016]
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR46708
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- None
- Other Sources
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr2:215360440...215436073 - (75.63 kb)
- Assembly version
- GRCh38
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- None
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.