Gene

FZD1

Species
Homo sapiens
Symbol
FZD1
Name
frizzled class receptor 1
Synonyms
  • DKFZp564G072
  • FLJ95923
Biotype
protein coding gene
Automated Description
Enables several functions, including PDZ domain binding activity; Wnt receptor activity; and Wnt-protein binding activity. Involved in several processes, including autocrine signaling; positive regulation of osteoblast differentiation; and regulation of DNA-templated transcription. Located in cell surface. Biomarker of breast carcinoma.
RGD Description
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues. [provided by RefSeq, Jul 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11309
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

          Model name
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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCh38
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            91.265M91.266M91.267M91.268M91.269M91.270M91.271M

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            FZD1 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
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              Genetic Interactions

              FZD1 role
              FZD1 genetic perturbation
              Interactor gene
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              Interactor genetic perturbation
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              Phenotype or trait
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