Gene

ALOX15

Species
Homo sapiens
Symbol
ALOX15
Name
arachidonate 15-lipoxygenase
Synonyms
  • 12-LOX
  • 12/15-lipoxygenase
Biotype
protein coding gene
Automated Description
Enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including cellular response to interleukin-13; fatty acid metabolic process; and positive regulation of ERK1 and ERK2 cascade. Located in cytoplasmic side of plasma membrane; cytosol; and lipid droplet. Biomarker of Alzheimer's disease.
RGD Description
This gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on various polyunsaturated fatty acid substrates to generate various bioactive lipid mediators such as eicosanoids, hepoxilins, lipoxins, and other molecules. The encoded enzyme and its reaction products have been shown to regulate inflammation and immunity. Multiple pseudogenes of this gene have been identified in the human genome. [provided by RefSeq, Aug 2017]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11771
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCh38
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            4.632M4.634M4.636M4.638M4.640M4.642M

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            ALOX15 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
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              Genetic Interactions

              ALOX15 role
              ALOX15 genetic perturbation
              Interactor gene
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