Gene

FENDRR

Species
Homo sapiens
Symbol
FENDRR
Name
FOXF1 adjacent non-coding developmental regulatory RNA
Synonyms
  • DKFZp666B056
  • DKFZp686B02156
Biotype
ncRNA gene
Automated Description
Predicted to enable core promoter sequence-specific DNA binding activity. Predicted to be involved in in utero embryonic development and lung development. Predicted to act upstream of or within several processes, including chromatin organization; embryonic lung development; and lateral mesoderm development.
RGD Description
This gene produces a spliced long non-coding RNA transcribed bidirectionally with FOXF1 on the opposite strand. A similar gene in mouse is essential for normal development of the heart and body wall. The encoded transcript is thought to act by binding to polycomb repressive complex 2 (PRC2) and/or TrxG/MLL complexes to promote the methylation of the promoters of target genes, thus reducing their expression. It has been suggested that this transcript may play a role in the progression of gastric cancer. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]
Cross References
Additional Information
Literature

Orthology

Gene tree
Not Available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
86.475M86.480M86.485M86.490M86.495M86.500M86.505M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions