Predicted to enable core promoter sequence-specific DNA binding activity. Predicted to be involved in in utero embryonic development and lung development. Predicted to act upstream of or within several processes, including chromatin organization; embryonic lung development; and lateral mesoderm development.
RGD Description
This gene produces a spliced long non-coding RNA transcribed bidirectionally with FOXF1 on the opposite strand. A similar gene in mouse is essential for normal development of the heart and body wall. The encoded transcript is thought to act by binding to polycomb repressive complex 2 (PRC2) and/or TrxG/MLL complexes to promote the methylation of the promoters of target genes, thus reducing their expression. It has been suggested that this transcript may play a role in the progression of gastric cancer. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]