Gene

GPER1

Species
Homo sapiens
Symbol
GPER1
Name
G protein-coupled estrogen receptor 1
Synonyms
  • CEPR
  • chemoattractant receptor-like 2
Biotype
protein coding gene
Automated Description
Enables chromatin binding activity; nuclear estrogen receptor activity; and steroid hormone binding activity. Involved in several processes, including cellular response to estradiol stimulus; positive regulation of metabolic process; and regulation of signal transduction. Located in several cellular components, including cytoplasmic vesicle; keratin filament; and nucleus. Biomarker of generalized anxiety disorder and melanoma.
RGD Description
This gene encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum and a member of the G-protein coupled receptor 1 family. This receptor binds estrogen and activates multiple downstream signaling pathways, leading to stimulation of adenylate cyclase and an increase in cyclic AMP levels, while also promoting intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. This receptor has been shown to play a role in diverse biological processes, including bone and nervous system development, metabolism, cognition, male fertility and uterine function. [provided by RefSeq, Aug 2017]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24226
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

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      Transgenic Alleles

      Species
      (carrying the transgene)
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCh38
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          GPER1 molecule type
          Interactor gene
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            Genetic Interactions

            GPER1 role
            GPER1 genetic perturbation
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