Version: 8.0.0
Date: Tue Jan 28 2025
GRIA3
Homo sapiensHGNC:4573
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

GRIA3

Species
Homo sapiens
Symbol
GRIA3
Name
glutamate ionotropic receptor AMPA type subunit 3
Synonyms
  • AMPA receptor subunit GluA3
  • AMPA-selective glutamate receptor 3
Biotype
protein coding gene
Automated Description
Enables AMPA glutamate receptor activity and ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential. Involved in protein heterotetramerization and protein homotetramerization. Located in plasma membrane. Implicated in syndromic X-linked intellectual disability 94.
RGD Description
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties. [provided by RefSeq, Jul 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR18966
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCh38
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          GRIA3 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
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            Genetic Interactions

            GRIA3 role
            GRIA3 genetic perturbation
            Interactor gene
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            Interactor role
            Interactor genetic perturbation
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            Phenotype or trait
            Source
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