Gene

GRM5

Species
Homo sapiens
Symbol
GRM5
Name
glutamate metabotropic receptor 5
Synonyms
  • glutamate receptor, metabotropic 5
  • GPRC1E
Biotype
protein coding gene
Automated Description
Enables identical protein binding activity; protein tyrosine kinase activator activity; and transmembrane signaling receptor activity. Involved in several processes, including cellular response to amyloid-beta; phospholipase C-activating G protein-coupled glutamate receptor signaling pathway; and positive regulation of calcium-mediated signaling. Located in plasma membrane. Is active in dendrite.
RGD Description
This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24060
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCh38
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            88.55M88.60M88.65M88.70M88.75M88.80M88.85M88.90M88.95M89.00M89.05M

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            GRM5 molecule type
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              Genetic Interactions

              GRM5 role
              GRM5 genetic perturbation
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