Version: 8.0.0
Date: Tue Jan 28 2025
GRM6
Homo sapiensHGNC:4598
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

GRM6

Species
Homo sapiens
Symbol
GRM6
Name
glutamate metabotropic receptor 6
Synonyms
  • CSNB1B
  • DKFZp686H1993
Biotype
protein coding gene
Automated Description
Enables glutamate receptor activity and protein homodimerization activity. Involved in G protein-coupled glutamate receptor signaling pathway; detection of light stimulus involved in visual perception; and positive regulation of calcium ion import across plasma membrane. Located in Golgi membrane; endoplasmic reticulum membrane; and plasma membrane. Implicated in congenital stationary night blindness 1B.
RGD Description
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Mutations in this gene result in congenital stationary night blindness type 1B. [provided by RefSeq, May 2018]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24060
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCh38
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          GRM6 molecule type
          Interactor gene
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            Genetic Interactions

            GRM6 role
            GRM6 genetic perturbation
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