Gene

GSTM3

Species
Homo sapiens
Symbol
GSTM3
Name
glutathione S-transferase mu 3
Synonyms
  • brain GST
  • brain type mu-glutathione S-transferase
Biotype
protein coding gene
Automated Description
Enables several functions, including glutathione binding activity; glutathione transferase activity; and protein homodimerization activity. Involved in several processes, including cellular detoxification of nitrogen compound; nitrobenzene metabolic process; and response to estrogen. Located in cytosol and intercellular bridge. Implicated in several diseases, including Alzheimer's disease; cystic fibrosis; larynx cancer; multiple sclerosis; and osteosarcoma. Biomarker of Alzheimer's disease; asthma; macular degeneration; and pulmonary emphysema.
RGD Description
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11571
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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None
Other Sources
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCh38
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            109.734M109.735M109.736M109.737M109.738M109.739M109.740M109.741M

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            GSTM3 molecule type
            Interactor gene
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              Genetic Interactions

              GSTM3 role
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