Gene

GSTT1

Species
Homo sapiens
Symbol
GSTT1
Name
glutathione S-transferase theta 1
Synonyms
  • glutathione S-transferase theta-1
  • glutathione s-transferase, theta 1
Biotype
protein coding gene
Automated Description
Enables glutathione peroxidase activity and glutathione transferase activity. Involved in glutathione metabolic process. Located in cytosol. Implicated in several diseases, including autoimmune disease (multiple); cancer (multiple); cardiovascular system disease (multiple); eye disease (multiple); and lung disease (multiple). Biomarker of anemia; exfoliation syndrome; and transitional cell carcinoma.
RGD Description
The protein encoded by this gene, glutathione S-transferase (GST) theta 1 (GSTT1), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT1 and GSTT2/GSTT2B share 55% amino acid sequence identity and may play a role in human carcinogenesis. The GSTT1 gene is haplotype-specific and is absent from 38% of the population. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR43917

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
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    Variant type
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
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        Models

        Model name
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          Sequence Feature Viewer

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          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          GSTT1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
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            Genetic Interactions

            GSTT1 role
            GSTT1 genetic perturbation
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