Gene

H3-3A

Species
Homo sapiens
Symbol
H3-3A
Name
H3.3 histone A
Synonyms
  • BRYLIB1
  • H3 histone family member 3A
Biotype
protein coding gene
Automated Description
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; RNA polymerase II core promoter sequence-specific DNA binding activity; and nucleosomal DNA binding activity. A structural constituent of chromatin. Involved in nucleosome assembly and positive regulation of cell growth. Located in chromosome, telomeric region and nucleoplasm. Part of nucleosome.
RGD Description
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded is a replication-independent member of the histone H3 family. [provided by RefSeq, Jul 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11426
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Mus musculusH3f3b9 of 10YesYes  
Mus musculusH3f3a9 of 10YesYes  
Rattus norvegicusH3f3a9 of 10YesYes  
Xenopus tropicalish3-3a8 of 9YesYes   
Xenopus tropicalish3-3b8 of 9YesYes   
Xenopus tropicalish3c132 of 9YesYes   
Danio rerioh3f3a9 of 10YesYes  
Danio rerioh3f3d8 of 10NoYes  
Danio reriosi:ch1073-429i10.38 of 10NoYes  
Danio rerioh3f3b.18 of 10NoYes  
Danio rerioh3f3c8 of 10NoYes  
Drosophila melanogasterHis3.3B8 of 9YesYes   
Drosophila melanogasterHis3.3A8 of 9YesYes   
Caenorhabditis eleganshis-717 of 9YesYes   
Caenorhabditis eleganshis-724 of 9NoYes   
Saccharomyces cerevisiaeHHT16 of 9YesYes   
Saccharomyces cerevisiaeHHT26 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
H3C14113699978 of 8  
H3C1213699968 of 8  
H3-7313697948 of 8  
H3-4413697938 of 8  
H3-5513696967 of 8  
H3Y2613691823 of 8  
H3Y1713491823 of 8  
CENPA813263523 of 8  

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
Phenotype Term
Annotation details
References
Agenesis of corpus callosum
Anteverted nares
Atrial septal defect
Autistic behavior
Autosomal dominant inheritance
Bicuspid aortic valve
Broad philtrum
Broad thumb
Cerebellar vermis hypoplasia
Cerebral cortical atrophy
Showing 1 - 10 of 67 rows
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
GRCh38
Viewer Help
226.062M226.063M226.064M226.065M226.066M226.067M226.068M226.069M226.070M226.071M226.072M
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
NC_000001.11:g.226071445A>Gvariant
SNP
  • missense variant
NC_000001.11:g.226064434A>Tvariant
SNP
  • missense variant
NC_000001.11:g.226064438T>Gvariant
SNP
  • missense variant
NC_000001.11:g.226071376G>Avariant
SNP
  • missense variant
NC_000001.11:g.226064371C>Gvariant
SNP
  • missense variant
NC_000001.11:g.226065676G>Avariant
SNP
  • missense variant
NC_000001.11:g.226065777C>Gvariant
SNP
  • missense variant
NC_000001.11:g.226071348C>Tvariant
SNP
  • splice region variant
NC_000001.11:g.226064429T>Cvariant
SNP
  • synonymous variant
NC_000001.11:g.226071394A>Gvariant
SNP
  • missense variant
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Transgenic Alleles

Species
(carrying the transgene)
Allele symbol
Transgenic construct
Expressed components
Knock-down targets
Regulatory regions
Has Disease Annotations
Has Phenotype Annotations
Drosophila melanogasterHsap\H3-3AK27M.UAS.Tag:FLAG,Tag:HA
  • UASt
Yes
Drosophila melanogasterHsap\H3-3AK27M.UAS.Tag:FLAG
  • UASt
Drosophila melanogasterHsap\H3-3AK27M.UAS.Tag:HA
  • UAS
Drosophila melanogasterHsap\H3-3AK27R.UAS.Tag:FLAG
  • UASt
Drosophila melanogasterHsap\H3-3AK36M.UAS.Tag:FLAG,Tag:HA
  • UASt
Drosophila melanogasterHsap\H3-3AK4A.UAS.Tag:FLAG,Tag:HA
  • UASt
Drosophila melanogasterHsap\H3-3AK4M.UAS.Tag:FLAG,Tag:HA
  • UASt
Drosophila melanogasterHsap\H3-3AK4M.UASp.Tag:FLAG,Tag:HA
  • UASp
Drosophila melanogasterHsap\H3-3AK79M.UAS.Tag:FLAG,Tag:HA
  • UASt
Drosophila melanogasterHsap\H3-3AK9M.UAS.Tag:FLAG,Tag:HA
  • UASt
Showing 1 - 10 of 14 rows
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Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
226.062M226.063M226.064M226.065M226.066M226.067M226.068M226.069M226.070M226.071M226.072M

Sequence Details

Loading...

Expression

Primary Sources
None
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

739 interactor genes based on 979 annotations
H3-3A molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
ABRAXAS1Homo sapiens
protein
  • proximity labelling technology
PMID:36089195
protein
ACTG1Homo sapiens
protein
  • affinity chromatography technology
PMID:23160995
protein
ACTL6AHomo sapiens
protein
  • proximity labelling technology
PMID:36089195
protein
ADNPHomo sapiens
protein
  • proximity labelling technology
PMID:36089195
protein
ADNP2Homo sapiens
protein
  • proximity labelling technology
PMID:36089195
protein
AFF4Homo sapiens
protein
  • proximity labelling technology
PMID:36089195
protein
AHCTF1Homo sapiens
protein
  • proximity labelling technology
PMID:36089195
protein
ANAPC7Homo sapiens
protein
  • proximity labelling technology
PMID:36089195
protein
ANLNHomo sapiens
protein
  • proximity labelling technology
PMID:36089195
protein
AP4M1Homo sapiens
protein
  • affinity chromatography technology
PMID:26496610
Showing 1 - 10 of 976 rows
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Genetic Interactions

H3-3A role
H3-3A genetic perturbation
Interactor gene
Interactor species
Interactor role
Interactor genetic perturbation
Interaction type
Phenotype or trait
Source
Reference
unspecified role
EGFRHomo sapiens
unspecified role
negative genetic interaction (sensu BioGRID)
  • Growth abnormality, viability
PMID:34373451
unspecified role
KRASHomo sapiens
unspecified role
negative genetic interaction (sensu BioGRID)
  • Growth abnormality, viability
PMID:34373451
unspecified role
RIT1Homo sapiens
unspecified role
negative genetic interaction (sensu BioGRID)
  • Growth abnormality, viability
PMID:34373451
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