Version: 8.0.0
Date: Tue Jan 28 2025
HAL
Homo sapiensHGNC:4806
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

HAL

Species
Homo sapiens
Symbol
HAL
Name
histidine ammonia-lyase
Synonyms
  • HIS
  • histidase
Biotype
protein coding gene
Automated Description
Enables histidine ammonia-lyase activity. Predicted to be involved in L-histidine catabolic process. Predicted to be located in cytosol. Implicated in histidinemia.
RGD Description
Histidine ammonia-lyase is a cytosolic enzyme catalyzing the first reaction in histidine catabolism, the nonoxidative deamination of L-histidine to trans-urocanic acid. Histidine ammonia-lyase defects cause histidinemia which is characterized by increased histidine and histamine and decreased urocanic acid in body fluids. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10362
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Mus musculusHal10 of 10YesYes☑☑☑☑☑☑☑☑☑☑  
Rattus norvegicusHal10 of 10YesYes☑☑☑☑☑☑☑☑☑☑  
Xenopus laevishal.2.L1 of 1YesYes          ☑ 
Xenopus laevishal.L1 of 1YesNo          ☑ 
Xenopus laevishal.2.S1 of 1YesYes          ☑ 
Xenopus tropicalishal.28 of 9YesYes☑ ☑☑☑☑☑☑☑☐  
Xenopus tropicalishal4 of 9NoYes☑ ☐☐☐☑☐☑☑☐  
Danio reriohal10 of 10YesYes☑ ☑☑☑☑☑☑☑☑ ☑
Caenorhabditis eleganshaly-19 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

No paralogs for the gene.

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
Phenotype Term
Annotation details
References
Abnormal speech pattern
Atypical behavior
Autosomal dominant inheritance
Autosomal recessive inheritance
Elevated urinary N-tau-ribosylhistidine level
Histidinuria
Hyperactivity
Hyperhistidinemia
Intellectual disability
Moderate global developmental delay
Showing 1 - 10 of 11 rows
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
No records match query. Try removing filters.
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    Alleles and Variants

    Genome location
    Assembly version
    GRCh38
    Viewer Help
    Data currently unavailable; sequence viewer under construction
    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
    NC_000012.12:g.95995917G>Avariant
    SNP
    • 5 prime UTR variant
    NC_000012.12:g.95973318A>Gvariant
    SNP
    • 3 prime UTR variant
    NC_000012.12:g.95974005T>Gvariant
    SNP
    • 3 prime UTR variant
    NC_000012.12:g.95976464T>Cvariant
    SNP
    • missense variant
    NC_000012.12:g.95994156C>Tvariant
    SNP
    • synonymous variant
    NC_000012.12:g.95995847G>Avariant
    SNP
    • missense variant
    NC_000012.12:g.95973702A>Cvariant
    SNP
    • 3 prime UTR variant
    NC_000012.12:g.95973804G>Cvariant
    SNP
    • 3 prime UTR variant
    NC_000012.12:g.95972920G>Avariant
    SNP
    • 3 prime UTR variant
    NC_000012.12:g.95972932A>Cvariant
    SNP
    • 3 prime UTR variant
    Showing 1 - 10 of 162 rows
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    View detailed Alleles/Variants information
    Download all Alleles/Variants for all genes of the species

    Transgenic Alleles

    No data available

    Models

    No data available

    Sequence Feature Viewer

    Genome location
    Assembly version
    GRCh38
    Viewer Help
    Data currently unavailable; sequence viewer under construction

    Sequence Details

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    Expression

    Primary Sources
    None
    Other Sources
    Must provide at least one subject
    Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

    Molecular Interactions

    135 interactor genes based on 167 annotations
    HAL molecule type
    Interactor gene
    Interactor species
    Interactor molecule type
    Detection methods
    Source
    Reference
    protein
    		AGPAT1Homo sapiens
    protein
    • affinity chromatography technology
    		PMID:33961781
    protein
    		AHDC1Homo sapiens
    protein
    • affinity chromatography technology
    		PMID:33961781
    protein
    		ALDH3A1Homo sapiens
    protein
    • affinity chromatography technology
    		PMID:33961781
    protein
    		APTXHomo sapiens
    protein
    • affinity chromatography technology
    		PMID:33961781
    protein
    		BPHLHomo sapiens
    protein
    • affinity chromatography technology
    		PMID:33961781
    protein
    		BUB1BHomo sapiens
    protein
    • affinity chromatography technology
    		PMID:32707033
    protein
    		C10orf120Homo sapiens
    protein
    • affinity chromatography technology
    		PMID:33961781
    protein
    		C18orf21Homo sapiens
    protein
    • affinity chromatography technology
    		PMID:33961781
    protein
    		C1orf35Homo sapiens
    protein
    • affinity chromatography technology
    		PMID:33961781
    protein
    		C6orf62Homo sapiens
    protein
    • affinity chromatography technology
    		PMID:33961781
    Showing 1 - 10 of 167 rows
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    Genetic Interactions

    No data available