Gene

HK2

Species
Homo sapiens
Symbol
HK2
Name
hexokinase 2
Synonyms
  • DKFZp686M1669
  • hexokinase type II
Biotype
protein coding gene
Automated Description
Enables glucokinase activity. Involved in several processes, including positive regulation of angiogenesis; positive regulation of type 2 mitophagy; and protein localization to mitochondrion. Acts upstream of or within apoptotic mitochondrial changes. Located in centrosome; cytosol; and mitochondrial outer membrane. Implicated in obesity and type 2 diabetes mellitus.
RGD Description
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells. [provided by RefSeq, Apr 2009]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR19443
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

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      Transgenic Alleles

      Species
      (carrying the transgene)
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCh38
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          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          HK2 molecule type
          Interactor gene
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            Genetic Interactions

            HK2 role
            HK2 genetic perturbation
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