Gene

HNMT

Species
Homo sapiens
Symbol
HNMT
Name
histamine N-methyltransferase
Synonyms
  • HMT
  • HNMT-S1
Biotype
protein coding gene
Automated Description
Enables histamine N-methyltransferase activity. Involved in histamine catabolic process and methylation. Located in centrosome; cytoplasm; and nucleoplasm. Is active in cytosol. Implicated in Parkinson's disease; asthma; atopic dermatitis; autosomal recessive intellectual developmental disorder 51; and essential tremor. Biomarker of Down syndrome; Huntington's disease; Pick's disease; and ulcerative colitis.
RGD Description
In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
Not Available
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Mus musculusHnmt9 of 10YesYes  
Rattus norvegicusHnmt9 of 10YesYes  
Xenopus laevishnmt.S1 of 1YesYes           
Xenopus laevishnmt.L1 of 1YesYes           
Xenopus tropicalishnmt8 of 9YesYes   
Danio reriohnmt9 of 10YesYes  
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

No paralogs for the gene.

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
Phenotype Term
Annotation details
References
Airway hyperresponsiveness
Asthma
Autosomal dominant inheritance
Autosomal recessive inheritance
Bronchoconstriction
Delayed speech and language development
Global developmental delay
Infantile onset
Intellectual disability
Intellectual disability, severe
Showing 1 - 10 of 13 rows
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

No data available

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
137.965M137.970M137.975M137.980M137.985M137.990M137.995M138.000M138.005M138.010M138.015M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions