Version: 8.0.0Date: Tue Jan 28 2025
Gene
HNRNPD
- Species
- Homo sapiens
- Symbol
- HNRNPD
- Name
- heterogeneous nuclear ribonucleoprotein D
- Synonyms
- ARE-binding protein AUFI, type A
- AU-rich element RNA binding protein 1, 37kDa
- Biotype
- protein coding gene
- Automated Description
- Enables RNA binding activity and telomeric DNA binding activity. Involved in post-transcriptional regulation of gene expression and regulation of circadian rhythm. Located in nucleoplasm. Part of mCRD-mediated mRNA stability complex and ribonucleoprotein complex. Biomarker of hepatocellular carcinoma.
- RGD Description
- This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants. [provided by RefSeq, Jul 2008]
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR48033
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
Sequence Feature Viewer
- Genome location
- Chr4:82352498...82374503 - (22.01 kb)
- Assembly version
- GRCh38
- Viewer Help
Data currently unavailable; sequence viewer under construction