Gene

HOXB13

Species
Homo sapiens
Symbol
HOXB13
Name
homeobox B13
Synonyms
  • homeo box B13
  • homeobox protein Hox-B13
Biotype
protein coding gene
Automated Description
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; methyl-CpG binding activity; and sequence-specific double-stranded DNA binding activity. Involved in angiogenesis and negative regulation of transcription by RNA polymerase II. Located in nucleoplasm. Implicated in ductal carcinoma in situ and renal cell carcinoma. Biomarker of cervical cancer; endometrial cancer; and prostate cancer.
RGD Description
This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated to play a role in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster at chromosome the 17q21-22 region. [provided by RefSeq, Jul 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45804
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
48.7250M48.7255M48.7260M48.7265M48.7270M48.7275M48.7280M48.7285M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions