Version: 8.0.0
Date: Tue Jan 28 2025
HOXD1
Homo sapiensHGNC:5132
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

HOXD1

Species
Homo sapiens
Symbol
HOXD1
Name
homeobox D1
Synonyms
  • homeo box 4G
  • homeo box D1
Biotype
protein coding gene
Automated Description
Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within embryonic skeletal system development; neuron differentiation; and sensory perception of pain. Located in nucleoplasm.
RGD Description
This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. This nuclear protein functions as a sequence-specific transcription factor that is involved in differentiation and limb development. Mutations in this gene have been associated with severe developmental defects on the anterior-posterior (a-p) limb axis. [provided by RefSeq, Jul 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45946
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Mus musculusHoxd110 of 10YesYes☑☑☑☑☑☑☑☑☑☑  
Rattus norvegicusHoxd110 of 10YesYes☑☑☑☑☑☑☑☑☑☑  
Xenopus laevishoxd1.L1 of 1YesYes          ☑ 
Xenopus laevishoxd1.S1 of 1YesYes          ☑ 
Xenopus tropicalishoxd19 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Danio reriohoxc1a2 of 10YesYes☑ ☐☐☐☐☐☑☐☐ ☐
Drosophila melanogasterlab4 of 9YesYes☑ ☐☐☐☑☑☑☐☐  
Caenorhabditis elegansceh-135 of 9YesYes☑ ☐☑☐☑☐☐☑☑  
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
HOXB1136145366 of 8☑ ☑☐☐☑☑☑☑ 
HOXA1236145366 of 8☑ ☑☐☐☑☑☑☑ 
HOXB3339137283 of 8☑ ☐☐☐☐☐☑☑ 
HOXA4438935283 of 8☑ ☐☐☐☐☐☑☑ 
HOXB5533939303 of 8☑ ☐☐☐☐☐☑☑ 
HOXD9632937313 of 8☑ ☐☐☐☐☐☑☑ 
HOXD8736935263 of 8☑ ☐☐☐☐☐☑☑ 
PDX1832239303 of 8☑ ☐☐☐☐☐☑☑ 
CDX2936139282 of 8☐ ☐☐☐☐☐☑☑ 
HOXA111034237263 of 8☑ ☐☐☐☐☐☑☑ 
HOXD31127845333 of 8☑ ☐☐☐☐☐☑☑ 
HOXA101236335282 of 8☑ ☐☐☐☐☐☑☐ 
HOXA131337834252 of 8☑ ☐☐☐☐☐☑☐ 
HOXB41430737283 of 8☑ ☐☐☐☐☐☑☑ 
HOXD41528340313 of 8☑ ☐☐☐☐☐☑☑ 
HOXA61626642323 of 8☑ ☐☐☐☐☐☑☑ 
HOXA31731139302 of 8☑ ☐☐☐☐☐☑☐ 
GBX21832637282 of 8☐ ☐☐☐☐☐☑☑ 
HOXB91929836283 of 8☑ ☐☐☐☐☐☑☑ 
HOXD112029337283 of 8☑ ☐☐☐☐☐☑☑ 
HOXD122129941282 of 8☑ ☐☐☐☐☐☑☐ 
HOXC42226943342 of 8☐ ☐☐☐☐☐☑☑ 
HOXA52324843333 of 8☑ ☐☐☐☐☐☑☑ 
HOXB72425741323 of 8☑ ☐☐☐☐☐☑☑ 
GBX12531437272 of 8☐ ☐☐☐☐☐☑☑ 
CDX12630138302 of 8☐ ☐☐☐☐☐☑☑ 
HOXA22728441302 of 8☑ ☐☐☐☐☐☑☐ 
HOXC92828640302 of 8☐ ☐☐☐☐☐☑☑ 
DBX12932237252 of 8☐ ☐☐☐☐☐☑☑ 
EMX13028838312 of 8☐ ☐☐☐☐☐☑☑ 
HOXB63124641323 of 8☑ ☐☐☐☐☐☑☑ 
GSX23228340302 of 8☑ ☐☐☐☐☐☑☐ 
HOXC113327041302 of 8☐ ☐☐☐☐☐☑☑ 
TLX33426938322 of 8☑ ☐☐☐☐☐☑☐ 
HOXC53522646372 of 8☐ ☐☐☐☐☐☑☑ 
MEOX13631035252 of 8☐ ☐☐☐☐☐☑☑ 
TLX13728236302 of 8☑ ☐☐☐☐☐☑☐ 
HOXA93826940282 of 8☐ ☐☐☐☐☐☑☑ 
HOXA73923139323 of 8☑ ☐☐☐☐☐☑☑ 
HOXB84020943333 of 8☑ ☐☐☐☐☐☑☑ 
HOXB24125939302 of 8☑ ☐☐☐☐☐☑☐ 
HOXC84225440302 of 8☐ ☐☐☐☐☐☑☑ 
RAX4325640282 of 8☐ ☐☐☐☐☐☑☑ 
NKX6-34430634222 of 8☐ ☐☐☐☐☐☑☑ 
GSX14527035272 of 8☐ ☐☐☐☐☐☑☑ 
TLX24624437322 of 8☑ ☐☐☐☐☐☑☐ 
HOXC64721242342 of 8☐ ☐☐☐☐☐☑☑ 
MEOX24816047342 of 8☐ ☐☐☐☐☐☑☑ 
HOXD104912449403 of 8☑ ☐☐☐☐☐☑☑ 
RAX25012247312 of 8☐ ☐☐☐☐☐☑☑ 
EMX2512 of 8☐ ☐☐☐☐☐☑☑ 
NKX6-2512 of 8☐ ☐☐☐☐☐☑☑ 
CDX4512 of 8☐ ☐☐☐☐☐☑☑ 
DLX4512 of 8☐ ☐☐☐☐☐☑☑ 
NKX3-1512 of 8☐ ☐☐☐☐☐☑☑ 
NKX6-1512 of 8☐ ☐☐☐☐☐☑☑ 
DBX2512 of 8☐ ☐☐☐☐☐☑☑ 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
No records match query. Try removing filters.
Showing 0 - 0 of 0 rows
per page

    Alleles and Variants

    Genome location
    Assembly version
    GRCh38
    Viewer Help
    Data currently unavailable; sequence viewer under construction
    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
    NC_000002.12:g.176189911G>Cvariant
    SNP
    • missense variant
    NC_000002.12:g.176188992C>Tvariant
    SNP
    • missense variant
    NC_000002.12:g.176189136G>Tvariant
    SNP
    • missense variant
    NC_000002.12:g.176189148A>Gvariant
    SNP
    • missense variant
    NC_000002.12:g.176189183G>Avariant
    SNP
    • missense variant
    NC_000002.12:g.176189253A>Gvariant
    SNP
    • missense variant
    NC_000002.12:g.176189063G>Avariant
    SNP
    • missense variant
    NC_000002.12:g.176189259A>Cvariant
    SNP
    • missense variant
    NC_000002.12:g.176189954C>Tvariant
    SNP
    • missense variant
    NC_000002.12:g.176189088C>Avariant
    SNP
    • missense variant
    Showing 1 - 10 of 20 rows
    per page
    View detailed Alleles/Variants information
    Download all Alleles/Variants for all genes of the species

    Transgenic Alleles

    No data available

    Models

    No data available

    Sequence Feature Viewer

    Genome location
    Assembly version
    GRCh38
    Viewer Help
    Data currently unavailable; sequence viewer under construction

    Sequence Details

    Loading...

    Expression

    Primary Sources
    None
    Other Sources
    Must provide at least one subject
    Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

    Molecular Interactions

    3 interactor genes based on 3 annotations
    HOXD1 molecule type
    Interactor gene
    Interactor species
    Interactor molecule type
    Detection methods
    Source
    Reference
    protein
    		HOXB1Homo sapiens
    protein
    • affinity chromatography technology
    		PMID:33961781
    protein
    		HOXC9Homo sapiens
    protein
    • two hybrid
    		PMID:20211142
    Showing 1 - 2 of 2 rows
    per page

    Genetic Interactions

    HOXD1 role
    HOXD1 genetic perturbation
    Interactor gene
    Interactor species
    Interactor role
    Interactor genetic perturbation
    Interaction type
    Phenotype or trait
    Source
    Reference
    unspecified role
    		KRASHomo sapiens
    unspecified role
    synthetic lethality (sensu BioGRID)
    • Growth abnormality
    		PMID:19490893
    Showing 1 - 1 of 1 rows
    per page