Gene

HPGD

Species
Homo sapiens
Symbol
HPGD
Name
15-hydroxyprostaglandin dehydrogenase
Synonyms
  • 15-hydroxyprostaglandin dehydrogenase (NAD(+))
  • 15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Biotype
protein coding gene
Automated Description
Enables several functions, including 15-hydroxyprostaglandin dehydrogenase (NAD+) activity; NAD+ binding activity; and prostaglandin E receptor activity. Involved in several processes, including prostaglandin metabolic process; regulation of prostaglandin catabolic process; and transforming growth factor beta receptor signaling pathway. Located in cytosol and nucleoplasm. Implicated in colon carcinoma and primary hypertrophic osteoarthropathy. Biomarker of growth hormone secreting pituitary adenoma; inflammatory bowel disease; prolactinoma; and pulmonary hypertension.
RGD Description
This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR44229
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

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      Transgenic Alleles

      Species
      (carrying the transgene)
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCh38
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          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          HPGD molecule type
          Interactor gene
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            Genetic Interactions

            HPGD role
            HPGD genetic perturbation
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