Enables several functions, including 15-hydroxyprostaglandin dehydrogenase (NAD+) activity; NAD+ binding activity; and prostaglandin E receptor activity. Involved in several processes, including prostaglandin metabolic process; regulation of prostaglandin catabolic process; and transforming growth factor beta receptor signaling pathway. Located in cytosol and nucleoplasm. Implicated in colon carcinoma and primary hypertrophic osteoarthropathy. Biomarker of growth hormone secreting pituitary adenoma; inflammatory bowel disease; prolactinoma; and pulmonary hypertension.
RGD Description
This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]