Version: 8.0.0
Date: Tue Jan 28 2025
HSPA8
Homo sapiensHGNC:5241
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

HSPA8

Species
Homo sapiens
Symbol
HSPA8
Name
heat shock protein family A (Hsp70) member 8
Synonyms
  • constitutive heat shock protein 70
  • epididymis luminal protein 33
Biotype
protein coding gene
Automated Description
Enables several functions, including ATP binding activity; ATP-dependent protein disaggregase activity; and signaling receptor binding activity. Involved in several processes, including negative regulation of cellular component organization; protein refolding; and protein targeting to lysosome involved in chaperone-mediated autophagy. Located in cytosol; extracellular exosome; and nucleus. Part of Prp19 complex; protein folding chaperone complex; and spliceosomal complex. Is active in extracellular space and lysosomal membrane. Implicated in Parkinson's disease and renal hypertension. Biomarker of several diseases, including cervical cancer; colorectal cancer; hypertension; multiple sclerosis (multiple); and pancreatic ductal adenocarcinoma.
RGD Description
This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR19375
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCh38
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          HSPA8 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            HSPA8 role
            HSPA8 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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