Gene

AOC3

Species
Homo sapiens
Symbol
AOC3
Name
amine oxidase copper containing 3
Synonyms
  • amine oxidase [copper-containing] 3
  • amine oxidase, copper containing 3
Biotype
protein coding gene
Automated Description
Enables several functions, including identical protein binding activity; metal ion binding activity; and protein heterodimerization activity. Involved in amine metabolic process and cell adhesion. Located in several cellular components, including cell surface; microvillus; and plasma membrane. Part of Golgi apparatus; early endosome; and endoplasmic reticulum. Biomarker of Alzheimer's disease; cerebral amyloid angiopathy; congestive heart failure; diabetes mellitus (multiple); and diabetic retinopathy.
RGD Description
This gene encodes a member of the semicarbazide-sensitive amine oxidase family. Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The encoded protein is localized to the cell surface, has adhesive properties as well as monoamine oxidase activity, and may be involved in leukocyte trafficking. Alterations in levels of the encoded protein may be associated with many diseases, including diabetes mellitus. A pseudogene of this gene has been described and is located approximately 9-kb downstream on the same chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10638
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
42.852M42.853M42.854M42.855M42.856M42.857M42.858M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions