Enables several functions, including cysteine-type endopeptidase inhibitor activity involved in apoptotic process; identical protein binding activity; and protein serine/threonine kinase binding activity. Involved in several processes, including nucleotide-binding activity domain, leucine rich repeat containing receptor signaling pathway; regulation of macromolecule metabolic process; and regulation of signal transduction. Acts upstream of with a negative effect on regulation of apoptotic process. Located in cytoplasm and nucleus. Implicated in X-linked lymphoproliferative syndrome 2 and prostate cancer. Biomarker of breast cancer (multiple); cervix uteri carcinoma in situ; colorectal cancer; prostate cancer; and renal cell carcinoma.
RGD Description
This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011]