Gene

XIAP

Species
Homo sapiens
Symbol
XIAP
Name
X-linked inhibitor of apoptosis
Synonyms
  • API3
  • apoptosis inhibitor 3
Biotype
protein coding gene
Automated Description
Enables several functions, including cysteine-type endopeptidase inhibitor activity involved in apoptotic process; identical protein binding activity; and protein serine/threonine kinase binding activity. Involved in several processes, including nucleotide-binding activity domain, leucine rich repeat containing receptor signaling pathway; regulation of macromolecule metabolic process; and regulation of signal transduction. Acts upstream of with a negative effect on regulation of apoptotic process. Located in cytoplasm and nucleus. Implicated in X-linked lymphoproliferative syndrome 2 and prostate cancer. Biomarker of breast cancer (multiple); cervix uteri carcinoma in situ; colorectal cancer; prostate cancer; and renal cell carcinoma.
RGD Description
This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10044
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
123.860M123.865M123.870M123.875M123.880M123.885M123.890M123.895M123.900M123.905M123.910M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions