Gene

ITGB3BP

Species
Homo sapiens
Symbol
ITGB3BP
Name
integrin subunit beta 3 binding protein
Synonyms
  • beta 3 endonexin
  • beta-3-endonexin
Biotype
protein coding gene
Automated Description
Predicted to be involved in cell adhesion; chromosome segregation; and signal transduction. Predicted to act upstream of or within negative regulation of epithelial cell apoptotic process and positive regulation of epithelial cell proliferation. Located in nucleoplasm. Part of inner kinetochore.
RGD Description
This gene encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces apoptosis in breast cancer cells through a caspase 2-mediated signaling pathway. This protein is also a component of the centromere-specific histone H3 variant nucleosome associated complex (CENP-NAC) and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR15581
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
63.35M63.40M63.45M63.50M63.55M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions