Gene

KCNK6

Species
Homo sapiens
Symbol
KCNK6
Name
potassium two pore domain channel subfamily K member 6
Synonyms
  • FLJ12282
  • inward rectifying potassium channel protein TWIK-2
Biotype
protein coding gene
Automated Description
Enables potassium channel activity. Predicted to be involved in positive regulation of NLRP3 inflammasome complex assembly; potassium ion transmembrane transport; and regulation of lysosome size. Predicted to act upstream of or within negative regulation of systemic arterial blood pressure and regulation of resting membrane potential. Located in lysosomal membrane.
RGD Description
This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This channel protein, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics. [provided by RefSeq, Jul 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11003
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
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    Transgenic Alleles

    Models

    Sequence Feature Viewer

    Genome location
    Assembly version
    GRCh38
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    38.320M38.322M38.324M38.326M38.328M38.330M38.332M

    Sequence Details

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    Expression

    Primary Sources
    None
    Other Sources
    Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

    Molecular Interactions

    Genetic Interactions