Version: 8.0.0
Date: Tue Jan 28 2025
KCNMB2
Homo sapiensHGNC:6286
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

KCNMB2

Species
Homo sapiens
Symbol
KCNMB2
Name
potassium calcium-activated channel subfamily M regulatory beta subunit 2
Synonyms
  • big potassium channel beta subunit 2
  • BK channel beta subunit 2
Biotype
protein coding gene
Automated Description
Enables calcium-activated potassium channel activity. Involved in detection of calcium ion; neuronal action potential; and potassium ion transport. Located in plasma membrane. Part of voltage-gated potassium channel complex.
RGD Description
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which decreases the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants of this gene. Additional variants are discussed in the literature, but their full length nature has not been described. [provided by RefSeq, Jul 2013]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10258
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCh38
            Viewer Help
            178.3M178.4M178.5M178.6M178.7M178.8M

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            KCNMB2 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
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              Genetic Interactions

              KCNMB2 role
              KCNMB2 genetic perturbation
              Interactor gene
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              Interactor role
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              Phenotype or trait
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