Version: 8.0.0Date: Tue Jan 28 2025
Gene
KDR
- Species
- Homo sapiens
- Symbol
- KDR
- Name
- kinase insert domain receptor
- Synonyms
- CD309
- fetal liver kinase 1
- Biotype
- protein coding gene
- Automated Description
- Enables several functions, including cell adhesion molecule binding activity; vascular endothelial growth factor binding activity; and vascular endothelial growth factor receptor activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; positive regulation of endothelial cell migration; and protein phosphorylation. Acts upstream of or within several processes, including branching involved in blood vessel morphogenesis; positive regulation of mitochondrial depolarization; and positive regulation of mitochondrial fission. Located in several cellular components, including Golgi apparatus; endosome; and membrane raft. Implicated in several diseases, including artery disease (multiple); breast angiosarcoma; gastrointestinal system cancer (multiple); macular degeneration (multiple); and pancreatic cancer (multiple). Biomarker of several diseases, including carcinoma (multiple); cerebrovascular disease (multiple); eye disease (multiple); inflammatory bowel disease (multiple); and systemic scleroderma (multiple).
- RGD Description
- Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009]
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR24416
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- None
- Other Sources
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr4:55078481...55125595 - (47.11 kb)
- Assembly version
- GRCh38
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- None
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.