Predicted to enable kisspeptin receptor binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway and positive regulation of cytosolic calcium ion concentration. Predicted to act upstream of or within decidualization; negative regulation of cell migration; and negative regulation of cell population proliferation. Predicted to be located in extracellular region. Implicated in hypogonadotropic hypogonadism 13 with or without anosmia. Biomarker of carcinoma (multiple); invasive ductal carcinoma; pre-eclampsia; trophoblastic neoplasm; and urinary bladder cancer.
RGD Description
This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin, stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal activation of GnRH neurons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues. [provided by RefSeq, Jun 2022]