Version: 8.0.0Date: Tue Jan 28 2025
Gene
KISS1
- Species
- Homo sapiens
- Symbol
- KISS1
- Name
- KiSS-1 metastasis suppressor
- Synonyms
- HH13
- KiSS-1
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable kisspeptin receptor binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway and positive regulation of cytosolic calcium ion concentration. Predicted to act upstream of or within decidualization; negative regulation of cell migration; and negative regulation of cell population proliferation. Predicted to be located in extracellular region. Implicated in hypogonadotropic hypogonadism 13 with or without anosmia. Biomarker of carcinoma (multiple); invasive ductal carcinoma; pre-eclampsia; trophoblastic neoplasm; and urinary bladder cancer.
- RGD Description
- This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin, stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal activation of GnRH neurons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues. [provided by RefSeq, Jun 2022]
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR16955
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- None
- Other Sources
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr1:204190341...204196491 - (6.15 kb)
- Assembly version
- GRCh38
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- None
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.