Gene

LHX3

Species
Homo sapiens
Symbol
LHX3
Name
LIM homeobox 3
Synonyms
  • CPHD3
  • DKFZp762A2013
Biotype
protein coding gene
Automated Description
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II-specific DNA-binding transcription factor binding activity; and sequence-specific DNA binding activity. Involved in inner ear development and positive regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Implicated in panhypopituitarism.
RGD Description
This gene encodes a member of a large family of proteins which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor that is required for pituitary development and motor neuron specification. Mutations in this gene cause combined pituitary hormone deficiency 3. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24208
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Mus musculusLhx310 of 10YesYes  
Rattus norvegicusLhx310 of 10YesYes  
Xenopus laevislhx3.S1 of 1YesYes           
Xenopus laevislhx3.L1 of 1YesYes           
Xenopus tropicalislhx35 of 9YesYes   
Danio reriolhx310 of 10YesYes  
Drosophila melanogasterLim38 of 9YesYes   
Caenorhabditis elegansceh-147 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
Phenotype Term
Annotation details
References
Abnormal cerebellum morphology
Abnormal circulating thyroglobulin concentration
Abnormal epiphysis morphology
Abnormal facial shape
Adrenocorticotropic hormone deficiency
Agenesis of corpus callosum
Anterior hypopituitarism
Anterior pituitary hypoplasia
Autosomal recessive inheritance
Bradycardia
Showing 1 - 10 of 59 rows
per page

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

No data available

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
136.197M136.198M136.199M136.200M136.201M136.202M136.203M136.204M136.205M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

177 interactor genes based on 197 annotations
LHX3 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
ABI2Homo sapiens
protein
  • two hybrid
PMID:32296183
protein
ACTN3Homo sapiens
protein
  • two hybrid
PMID:32296183
protein
AIF1LHomo sapiens
protein
  • two hybrid
PMID:32296183
protein
ANKRD45Homo sapiens
protein
  • two hybrid
PMID:32296183
protein
ANP32AHomo sapiens
protein
  • affinity chromatography technology
PMID:23861948
protein
ANP32AHomo sapiens
protein
  • pull down
PMID:23861948
protein
ARID2Homo sapiens
protein
  • proximity labelling technology
PMID:35140242
protein
ARID1AHomo sapiens
protein
  • proximity labelling technology
PMID:35140242
protein
ARID1BHomo sapiens
protein
  • proximity labelling technology
PMID:35140242
protein
ARID3AHomo sapiens
protein
  • proximity labelling technology
PMID:35140242
Showing 1 - 10 of 197 rows
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Genetic Interactions