ADP-ribosylation factor domain-containing protein 1
Biotype
protein coding gene
Automated Description
Enables several functions, including GTPase activity; guanyl ribonucleotide binding activity; and identical protein binding activity. Involved in positive regulation of autophagy and protein ubiquitination. Located in Golgi membrane and lysosomal membrane. Is active in cytoplasm.
RGD Description
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described. [provided by RefSeq, Jul 2008]