Gene

TRIM23

Species
Homo sapiens
Symbol
TRIM23
Name
tripartite motif containing 23
Synonyms
  • ADP-ribosylation factor domain protein 1, 64kDa
  • ADP-ribosylation factor domain-containing protein 1
Biotype
protein coding gene
Automated Description
Enables several functions, including GTPase activity; guanyl ribonucleotide binding activity; and identical protein binding activity. Involved in positive regulation of autophagy and protein ubiquitination. Located in Golgi membrane and lysosomal membrane. Is active in cytoplasm.
RGD Description
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described. [provided by RefSeq, Jul 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11711
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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      Alleles and Variants

      Allele/Variant Symbol
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      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCh38
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            65.590M65.595M65.600M65.605M65.610M65.615M65.620M65.625M

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            TRIM23 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
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              Genetic Interactions

              TRIM23 role
              TRIM23 genetic perturbation
              Interactor gene
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