Gene

LTBP3

Species
Homo sapiens
Symbol
LTBP3
Name
latent transforming growth factor beta binding protein 3
Synonyms
  • DASS
  • DKFZp586M2123
Biotype
protein coding gene
Automated Description
Enables transforming growth factor beta binding activity. Involved in positive regulation of mesenchymal stem cell differentiation; positive regulation of mesenchymal stem cell proliferation; and transforming growth factor beta receptor signaling pathway. Located in collagen-containing extracellular matrix. Implicated in brachyolmia-amelogenesis imperfecta syndrome and geleophysic dysplasia 3.
RGD Description
The protein encoded by this gene forms a complex with transforming growth factor beta (TGF-beta) proteins and may be involved in their subcellular localization. Activation of this complex requires removal of the encoded binding protein. This protein also may play a structural role in the extracellular matrix. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24040
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCh38
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            65.540M65.542M65.544M65.546M65.548M65.550M65.552M65.554M65.556M65.558M

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            LTBP3 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
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              Genetic Interactions

              LTBP3 role
              LTBP3 genetic perturbation
              Interactor gene
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              Interactor genetic perturbation
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              Phenotype or trait
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