Version: 8.1.0Date: Fri Apr 18 2025
Gene
LTF
- Species
- Homo sapiens
- Symbol
- LTF
- Name
- lactotransferrin
- Synonyms
- ALF
- apolactoferrin
- Biotype
- protein coding gene
- Automated Description
- Enables several functions, including heparin binding activity; lipopolysaccharide binding activity; and membrane destabilizing activity. Involved in several processes, including defense response to symbiont; positive regulation of cell population proliferation; and regulation of signal transduction. Located in cell surface; extracellular space; and specific granule. Part of protein-containing complex. Implicated in candidiasis; lung non-small cell carcinoma; and renal cell carcinoma. Biomarker of connective tissue disease; inflammatory bowel disease; and prostate calculus.
- RGD Description
- This gene is a member of the transferrin family of genes and its protein product is found in the secondary granules of neutrophils. The protein is a major iron-binding protein in milk and body secretions with an antimicrobial activity, making it an important component of the non-specific immune system. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. Antimicrobial, antiviral, antifungal and antiparasitic activity has been found for this protein and its peptides. Activity against both DNA and RNA viruses has been found, including activity against SARS-CoV-2, and HIV. [provided by RefSeq, Jul 2021]
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR11485
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- None
- Other Sources
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr3:46435645...46485234 - (49.59 kb)
- Assembly version
- GRCh38
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- None
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.