Gene

MAPK3

Species
Homo sapiens
Symbol
MAPK3
Name
mitogen-activated protein kinase 3
Synonyms
  • ERK-1
  • ERK1
Biotype
protein coding gene
Automated Description
Enables several functions, including MAP kinase activity; identical protein binding activity; and phosphatase binding activity. Involved in several processes, including cell surface receptor signaling pathway; intracellular signal transduction; and regulation of intracellular signal transduction. Acts upstream of or within positive regulation of telomere maintenance. Located in nuclear envelope. Implicated in Parkinson's disease; carcinoma (multiple); and pulmonary hypertension. Biomarker of endometrial adenocarcinoma; endometrial carcinoma; obesity; and schizophrenia.
RGD Description
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq, Jul 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24055
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
No data available

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
30.115M30.116M30.117M30.118M30.119M30.120M30.121M30.122M30.123M

Sequence Details

Loading...

Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions