Enables several functions, including MAP kinase activity; identical protein binding activity; and phosphatase binding activity. Involved in several processes, including cell surface receptor signaling pathway; intracellular signal transduction; and regulation of intracellular signal transduction. Acts upstream of or within positive regulation of telomere maintenance. Located in nuclear envelope. Implicated in Parkinson's disease; carcinoma (multiple); and pulmonary hypertension. Biomarker of endometrial adenocarcinoma; endometrial carcinoma; obesity; and schizophrenia.
RGD Description
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq, Jul 2008]