Version: 8.0.0
Date: Tue Jan 28 2025
MAPK8IP1
Homo sapiensHGNC:6882
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

MAPK8IP1

Species
Homo sapiens
Symbol
MAPK8IP1
Name
mitogen-activated protein kinase 8 interacting protein 1
Synonyms
  • C-Jun-amino-terminal kinase-interacting protein 1
  • IB-1
Biotype
protein coding gene
Automated Description
Enables MAP-kinase scaffold activity and kinesin binding activity. Predicted to be involved in several processes, including JNK cascade; regulation of CD8-positive, alpha-beta T cell proliferation; and regulation of JNK cascade. Predicted to act upstream of or within JUN phosphorylation; negative regulation of intrinsic apoptotic signaling pathway; and regulation of DNA-templated transcription. Located in cytoplasm and plasma membrane. Implicated in type 2 diabetes mellitus.
RGD Description
This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq, May 2011]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR47437
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

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    Allele Synonyms
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCh38
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          MAPK8IP1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
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            Genetic Interactions

            MAPK8IP1 role
            MAPK8IP1 genetic perturbation
            Interactor gene
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            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
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