Enables arylsulfatase activity. Predicted to be involved in skeletal system development. Located in Golgi apparatus. Implicated in X-linked chondrodysplasia punctata 1 and chondrodysplasia punctata.
RGD Description
Arylsulfatase E is a member of the sulfatase family. It is glycosylated postranslationally and localized to the golgi apparatus. Sulfatases are essential for the correct composition of bone and cartilage matrix. X-linked chondrodysplasia punctata, a disease characterized by abnormalities in cartilage and bone development, has been linked to mutations in this gene. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on the Y chromosome. [provided by RefSeq, Sep 2013]