Version: 8.0.0Date: Tue Jan 28 2025
Gene
MSRA
- Species
- Homo sapiens
- Symbol
- MSRA
- Name
- methionine sulfoxide reductase A
- Synonyms
- cytosolic methionine-S-sulfoxide reductase
- mitochondrial peptide methionine sulfoxide reductase
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable L-methionine-(S)-S-oxide reductase activity and peptide-methionine (S)-S-oxide reductase activity. Predicted to be involved in cellular response to oxidative stress. Located in several cellular components, including actin cytoskeleton; midbody; and nucleoplasm.
- RGD Description
- This gene encodes a ubiquitous and highly conserved protein that carries out the enzymatic reduction of methionine sulfoxide to methionine. Human and animal studies have shown the highest levels of expression in kidney and nervous tissue. The protein functions in the repair of oxidatively damaged proteins to restore biological activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR42799
Stringency:
Additional filters to further constrain the results:
| Species | Gene symbol | Count | Best | Best reverse | Method Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN |
|---|---|---|---|---|---|
| Mus musculus | Msra | 10 of 10 | Yes | Yes | ☑☑☑☑☑☑☑☑☑☑ |
| Rattus norvegicus | Msra | 10 of 10 | Yes | Yes | ☑☑☑☑☑☑☑☑☑☑ |
| Xenopus laevis | msra.2.L | 1 of 1 | Yes | No | ☑ |
| Xenopus laevis | msra.L | 1 of 1 | Yes | Yes | ☑ |
| Xenopus tropicalis | msra | 5 of 9 | Yes | Yes | ☑ ☐☐☑☑☐☑☑☐ |
| Danio rerio | msraa | 10 of 10 | Yes | Yes | ☑ ☑☑☑☑☑☑☑☑ ☑ |
| Danio rerio | msrab | 3 of 10 | No | Yes | ☑ ☐☐☑☐☐☑☐☐ ☐ |
| Drosophila melanogaster | MsrA | 6 of 9 | Yes | Yes | ☑ ☑☑☐☑☑☐☐☑ |
| Caenorhabditis elegans | msra-1 | 5 of 9 | Yes | Yes | ☑ ☑☑☐☑☑☐☐☐ |
| Saccharomyces cerevisiae | MXR1 | 6 of 9 | Yes | Yes | ☑ ☑☑☑☐☑☐☐☑ |
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
Species | Gene | Association | Disease Qualifier | Disease | Evidence | Source | Based On | References |
|---|---|---|---|---|---|---|---|---|
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Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
|---|---|---|---|---|---|---|---|
| No records match query. Try removing filters. | |||||||
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
|---|---|---|---|---|---|---|---|
| No records match query. Try removing filters. | |||||||
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
|---|---|---|---|---|---|
| No records match query. Try removing filters. | |||||
Showing 0 - 0 of 0 rows
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Sequence Feature Viewer
- Genome location
- Chr8:10054292...10428891 + (374.60 kb)
- Assembly version
- GRCh38
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- None
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.