Version: 8.0.0Date: Tue Jan 28 2025
Gene
MYC
- Species
- Homo sapiens
- Symbol
- MYC
- Name
- MYC proto-oncogene, bHLH transcription factor
- Synonyms
- avian myelocytomatosis viral oncogene homolog
- bHLHe39
- Biotype
- protein coding gene
- Automated Description
- Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; SCF ubiquitin ligase complex binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including ERK1 and ERK2 cascade; regulation of fibroblast proliferation; and regulation of macromolecule metabolic process. Acts upstream of with a positive effect on negative regulation of gene expression via chromosomal CpG island methylation. Acts upstream of or within positive regulation of cell population proliferation and regulation of gene expression. Located in chromatin; nucleus; and rough endoplasmic reticulum. Part of Myc-Max complex and RNA polymerase II transcription repressor complex. Implicated in several diseases, including angiosarcoma; demyelinating disease; hematologic cancer (multiple); lung adenocarcinoma; and prostate cancer (multiple). Biomarker of several diseases, including hepatitis C; leukemia (multiple); liver disease (multiple); polycystic kidney disease 1; and urinary system cancer (multiple).
- RGD Description
- This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017]
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR45851
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- None
- Other Sources
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr8:127735434...127742951 + (7.52 kb)
- Assembly version
- GRCh38
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- None
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.