Gene

NCOA1

Species
Homo sapiens
Symbol
NCOA1
Name
nuclear receptor coactivator 1
Synonyms
  • bHLHe42
  • bHLHe74
Biotype
protein coding gene
Automated Description
Enables nuclear estrogen receptor binding activity and nuclear receptor coactivator activity. Involved in mRNA transcription by RNA polymerase II; nuclear receptor-mediated steroid hormone signaling pathway; and positive regulation of transcription from RNA polymerase II promoter by galactose. Acts upstream of or within positive regulation of DNA-templated transcription. Located in several cellular components, including chromatin; cytosol; and nucleoplasm. Part of RNA polymerase II transcription regulator complex. Biomarker of breast carcinoma; endometrial carcinoma; and prostate cancer.
RGD Description
The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10684
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
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24.50M24.55M24.60M24.65M24.70M24.75M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions